Hydrophobic forces are responsible for the folding of a highly potent natriuretic peptide analogue at a membrane mimetic surface: An NMR study

Biopolymers ◽  
1997 ◽  
Vol 42 (1) ◽  
pp. 37-48 ◽  
Author(s):  
Katharine A. Carpenter ◽  
Brian C. Wilkes ◽  
André De Léan ◽  
Alain Fournier ◽  
Peter W. Schiller
Keyword(s):  
Natriuretic Peptide ◽  
Peptide Analogue ◽  
Nmr Study ◽  
Membrane Mimetic

C-Type natriuretic peptide analogue therapy in children with achondroplasia

2020 ◽  
Author(s):  
Savarirayan R ◽  
Irving M ◽  
Bacino CA ◽  
Bostwick B ◽  
Charrow J ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Peptide Analogue

A novel method for the large-scale production of PG-CNP37, a C-type natriuretic peptide analogue

2013 ◽  
Vol 164 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Shinong Long ◽  
Daniel J. Wendt ◽  
Sean M. Bell ◽  
Timothy W. Taylor ◽  
Jean-Yves Dewavrin ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Large Scale ◽  
Scale Production ◽  
Peptide Analogue ◽  
Large Scale Production ◽  
Novel Method

scholarly journals C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia

2019 ◽  
Vol 381 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Ravi Savarirayan ◽  
Melita Irving ◽  
Carlos A. Bacino ◽  
Bret Bostwick ◽  
Joel Charrow ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Peptide Analogue

Immunoelectron microscope detection of C-type natriuretic peptide in normal human atrial tissue

1993 ◽  
Vol 51 ◽  
pp. 388-389
Author(s):  
Chi-Ming Wei ◽  
Margaret Hukee ◽  
Christopher G.A. McGregor ◽  
John C. Burnett
Keyword(s):  
Amino Acid ◽  
Natriuretic Peptide ◽  
Vascular Tone ◽  
Cardiac Tissue ◽  
Ring Structure ◽  
Terminal Amino Acid ◽  
Amino Acid Peptide ◽  
Normal Human ◽  
Terminal Amino ◽  
The Brain

C-type natriuretic peptide (CNP) is a newly identified peptide that is structurally related to atrial (ANP) and brain natriuretic peptide (BNP). CNP exists as a 22-amino acid peptide and like ANP and BNP has a 17-amino acid ring formed by a disulfide bond. Unlike these two previously identified cardiac peptides, CNP lacks the COOH-terminal amino acid extension from the ring structure. ANP, BNP and CNP decrease cardiac preload, but unlike ANP and BNP, CNP is not natriuretic. While ANP and BNP have been localized to the heart, recent investigations have failed to detect CNP mRNA in the myocardium although small concentrations of CNP are detectable in the porcine myocardium. While originally localized to the brain, recent investigations have localized CNP to endothelial cells consistent with a paracrine role for CNP in the control of vascular tone. While CNP has been detected in cardiac tissue by radioimmunoassay, no studies have demonstrated CNP localization in normal human heart by immunoelectron microscopy.

Arylation of enelactams using TIPSOTf: reaction scope and mechanistic insight

2021 ◽  
Author(s):  
Tomasz J. Idzik ◽  
Zofia M. Myk ◽  
Łukasz Struk ◽  
Magdalena Perużyńska ◽  
Gabriela Maciejewska ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Multinuclear Nmr ◽  
Mechanistic Insight ◽  
Nmr Study ◽  
Wide Range

Triisopropylsilyltrifluoromethanesulfonate can be effectively used for the arylation of a wide range of enelactams. The multinuclear NMR study provided deep insights into the reaction mechanism.

Synthesis and secretion of atrial natriuretic peptide by BON cells: Stimulation by PMA and cGMP

2001 ◽  
Vol 120 (5) ◽  
pp. A682-A682
Author(s):  
W GOWERJR ◽  
G CARTER ◽  
C LANDON ◽  
W GOWERIII ◽  
J DIETZ ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Bon Cells ◽  
Atrial Natriuretic
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